EML4-CASK Fusion FISH Probe
The EML4-CASK Fusion FISH Probe is used to confirm a fusion of the EML4 and CASK genes. The fusion of the EML4 and CASK genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML4-CASK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-RERE | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-REOR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-REGO | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-REGR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-REAQ | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-ORRE | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-OROR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-ORGO | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GORE | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GOOR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GOGO | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GOGR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GRRE | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GROR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GRGO | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GRGR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-AQRE | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-AQOR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-AQGO | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-AQGR | 20 (40 μL) | 200 μL |
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| EML4-CASK-20-AQAQ | 20 (40 μL) | 200 μL |
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CASK Gene Summary
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: Calcium/calmodulin Dependent Serine Protein Kinase
Chromosome: CHRX: 41374188 -41782287
Locus: Xp11.4
EML4 Gene Summary
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Echinoderm Microtubule Associated Protein Like 4
Chromosome: CHR2: 42396489 -42559688
Locus: 2p21
Gene Diseases
The EML4 CASK Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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