EML4-NTRK3 Fusion FISH Probe
The EML4-NTRK3 Fusion FISH Probe is used to confirm a fusion of the EML4 and NTRK3 genes. The fusion of the EML4 and NTRK3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML4-NTRK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-RERE | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-REOR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-REGO | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-REGR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-REAQ | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-ORRE | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-OROR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-ORGO | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GORE | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GOOR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GOGO | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GOGR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GRRE | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GROR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GRGO | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GRGR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-AQRE | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-AQOR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-AQGO | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-AQGR | 20 (40 μL) | 200 μL |
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| EML4-NTRK3-20-AQAQ | 20 (40 μL) | 200 μL |
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NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 3
Chromosome: CHR15: 88419987 -88799962
Locus: 15q25.3
EML4 Gene Summary
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Echinoderm Microtubule Associated Protein Like 4
Chromosome: CHR2: 42396489 -42559688
Locus: 2p21
Gene Diseases
The EML4 NTRK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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