ENG-AK1 Fusion FISH Probe
The ENG-AK1 Fusion FISH Probe is used to confirm a fusion of the ENG and AK1 genes. The fusion of the ENG and AK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ENG-AK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-RERE | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-REOR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-REGO | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-REGR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-OROR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GORE | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GROR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ENG-AK1-20-AQAQ | 20 (40 μL) | 200 μL |
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AK1 Gene Summary
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Adenylate Kinase 1
Chromosome: CHR9: 130628758 -130640022
Locus: 9q34.11
ENG Gene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Name: Endoglin
Chromosome: CHR9: 130577290 -130617047
Locus: 9q34.11
Gene Diseases
The ENG AK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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