ENPP1-INSR Fusion FISH Probe
The ENPP1-INSR Fusion FISH Probe is used to confirm a fusion of the ENPP1 and INSR genes. The fusion of the ENPP1 and INSR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ENPP1-INSR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-RERE | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-REOR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-REGO | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-REGR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-REAQ | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-ORRE | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-OROR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-ORGO | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GORE | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GOOR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GOGO | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GOGR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GRRE | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GROR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GRGO | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GRGR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-AQRE | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-AQOR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-AQGO | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-AQGR | 20 (40 μL) | 200 μL |
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| ENPP1-INSR-20-AQAQ | 20 (40 μL) | 200 μL |
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INSR Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Insulin Receptor
Chromosome: CHR19: 7112265 -7294011
Locus: 19p13.2
ENPP1 Gene Summary
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
Gene Name: Ectonucleotide Pyrophosphatase/phosphodiesterase 1
Chromosome: CHR6: 132129155 -132216295
Locus: 6q23.2
Gene Diseases
The ENPP1 INSR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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