ENPP1-RIPPLY2 Fusion FISH Probe
The ENPP1-RIPPLY2 Fusion FISH Probe is used to confirm a fusion of the ENPP1 and RIPPLY2 genes. The fusion of the ENPP1 and RIPPLY2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ENPP1-RIPPLY2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-RERE | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-REOR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-REGO | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-REGR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-REAQ | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-ORRE | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-OROR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-ORGO | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GORE | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GOOR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GOGO | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GOGR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GRRE | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GROR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GRGO | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GRGR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-AQRE | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-AQOR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-AQGO | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-AQGR | 20 (40 μL) | 200 μL |
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| ENPP1-RIPPLY2-20-AQAQ | 20 (40 μL) | 200 μL |
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ENPP1 Gene Summary
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
Gene Name: Ectonucleotide Pyrophosphatase/phosphodiesterase 1
Chromosome: CHR6: 132129155 -132216295
Locus: 6q23.2
RIPPLY2 Gene Summary
This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Ripply Transcriptional Repressor 2
Chromosome: CHR6: 84562984 -84567234
Locus: 6q14.2
Gene Diseases
The ENPP1 RIPPLY2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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