EP300-BCOR Fusion FISH Probe
The EP300-BCOR Fusion FISH Probe is used to confirm a fusion of the EP300 and BCOR genes. The fusion of the EP300 and BCOR genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EP300-BCOR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-RERE | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-REOR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-REGO | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-REGR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-REAQ | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-ORRE | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-OROR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-ORGO | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-ORAQ | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GORE | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GOOR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GOGO | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GOGR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GOAQ | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GRRE | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GROR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GRGO | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GRGR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-GRAQ | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-AQRE | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-AQOR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-AQGO | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-AQGR | 20 (40 μL) | 200 μL |
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| EP300-BCOR-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
BCOR Gene Summary
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
Gene Name: BCL6 Corepressor
Chromosome: CHRX: 39910498 -40036582
Locus: Xp11.4
Gene Diseases
The EP300 BCOR Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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