EP300-HAUS8 Fusion FISH Probe
The EP300-HAUS8 Fusion FISH Probe is used to confirm a fusion of the EP300 and HAUS8 genes. The fusion of the EP300 and HAUS8 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EP300-HAUS8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-RERE | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-REOR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-REGO | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-REGR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-REAQ | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-ORRE | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-OROR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-ORGO | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-ORAQ | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GORE | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GOOR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GOGO | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GOGR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GOAQ | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GRRE | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GROR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GRGO | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GRGR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-GRAQ | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-AQRE | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-AQOR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-AQGO | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-AQGR | 20 (40 μL) | 200 μL |
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| EP300-HAUS8-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
HAUS8 Gene Summary
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Gene Name: HAUS Augmin Like Complex Subunit 8
Chromosome: CHR19: 17160570 -17186343
Locus: 19p13.11
Gene Diseases
The EP300 HAUS8 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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