EP300-TNRC6B Fusion FISH Probe
The EP300-TNRC6B Fusion FISH Probe is used to confirm a fusion of the EP300 and TNRC6B genes. The fusion of the EP300 and TNRC6B genes has been associated with Stomach Adenocarcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EP300-TNRC6B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-RERE | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-REOR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-REGO | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-REGR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-REAQ | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-ORRE | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-OROR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-ORGO | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-ORAQ | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GORE | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GOOR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GOGO | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GOGR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GOAQ | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GRRE | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GROR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GRGO | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GRGR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-GRAQ | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-AQRE | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-AQOR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-AQGO | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-AQGR | 20 (40 μL) | 200 μL |
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| EP300-TNRC6B-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
TNRC6B Gene Summary
The Trinucleotide Repeat Containing 6B (TNRC6B) gene is located on chr22 :40440820-40731812 at 22q13.1.
Gene Name: Trinucleotide Repeat Containing 6B
Chromosome: CHR22: 40440820 -40731812
Locus: 22q13.1
Gene Diseases
The EP300 TNRC6B Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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