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EP300-TTC28 Fusion FISH Probe

The EP300-TTC28 Fusion FISH Probe is used to confirm a fusion of the EP300 and TTC28 genes. The fusion of the EP300 and TTC28 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
EP300-TTC28-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
EP300-TTC28-20-RERE 20 (40 μL) 200 μL
EP300-TTC28-20-REOR 20 (40 μL) 200 μL
EP300-TTC28-20-REGO 20 (40 μL) 200 μL
EP300-TTC28-20-REGR 20 (40 μL) 200 μL
EP300-TTC28-20-REAQ 20 (40 μL) 200 μL
EP300-TTC28-20-ORRE 20 (40 μL) 200 μL
EP300-TTC28-20-OROR 20 (40 μL) 200 μL
EP300-TTC28-20-ORGO 20 (40 μL) 200 μL
EP300-TTC28-20-ORAQ 20 (40 μL) 200 μL
EP300-TTC28-20-GORE 20 (40 μL) 200 μL
EP300-TTC28-20-GOOR 20 (40 μL) 200 μL
EP300-TTC28-20-GOGO 20 (40 μL) 200 μL
EP300-TTC28-20-GOGR 20 (40 μL) 200 μL
EP300-TTC28-20-GOAQ 20 (40 μL) 200 μL
EP300-TTC28-20-GRRE 20 (40 μL) 200 μL
EP300-TTC28-20-GROR 20 (40 μL) 200 μL
EP300-TTC28-20-GRGO 20 (40 μL) 200 μL
EP300-TTC28-20-GRGR 20 (40 μL) 200 μL
EP300-TTC28-20-GRAQ 20 (40 μL) 200 μL
EP300-TTC28-20-AQRE 20 (40 μL) 200 μL
EP300-TTC28-20-AQOR 20 (40 μL) 200 μL
EP300-TTC28-20-AQGO 20 (40 μL) 200 μL
EP300-TTC28-20-AQGR 20 (40 μL) 200 μL
EP300-TTC28-20-AQAQ 20 (40 μL) 200 μL

EP300 Gene Summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Gene Name: E1A Binding Protein P300

Chromosome: CHR22: 41488613 -41576081

Locus: 22q13.2

TTC28 Gene Summary

The Tetratricopeptide Repeat Domain 28 (TTC28) gene is located on chr22 :28374001-29075853 at 22q12.1.

Gene Name: Tetratricopeptide Repeat Domain 28

Chromosome: CHR22: 28374001 -29075853

Locus: 22q12.1

Gene Diseases

The EP300 TTC28 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.