EP300-XPNPEP3 Fusion FISH Probe
The EP300-XPNPEP3 Fusion FISH Probe is used to confirm a fusion of the EP300 and XPNPEP3 genes. The fusion of the EP300 and XPNPEP3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EP300-XPNPEP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-RERE | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-REOR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-REGO | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-REGR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-REAQ | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-ORRE | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-OROR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-ORGO | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GORE | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GOOR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GOGO | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GOGR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GRRE | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GROR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GRGO | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GRGR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-AQRE | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-AQOR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-AQGO | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-AQGR | 20 (40 μL) | 200 μL |
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| EP300-XPNPEP3-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
XPNPEP3 Gene Summary
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011]
Gene Name: X-prolyl Aminopeptidase 3
Chromosome: CHR22: 41253084 -41328823
Locus: 22q13.2
Gene Diseases
The EP300 XPNPEP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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