EPB41L1-TGM3 Fusion FISH Probe
The EPB41L1-TGM3 Fusion FISH Probe is used to confirm a fusion of the EPB41L1 and TGM3 genes. The fusion of the EPB41L1 and TGM3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPB41L1-TGM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-RERE | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-REOR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-REGO | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-REGR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-REAQ | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-ORRE | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-OROR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-ORGO | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GORE | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GOOR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GOGO | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GOGR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GRRE | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GROR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GRGO | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GRGR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-AQRE | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-AQOR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-AQGO | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-AQGR | 20 (40 μL) | 200 μL |
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| EPB41L1-TGM3-20-AQAQ | 20 (40 μL) | 200 μL |
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EPB41L1 Gene Summary
Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: Erythrocyte Membrane Protein Band 4.1 Like 1
Chromosome: CHR20: 34700347 -34820721
Locus: 20q11.23
TGM3 Gene Summary
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
Gene Name: Transglutaminase 3
Chromosome: CHR20: 2276612 -2321725
Locus: 20p13
Gene Diseases
The EPB41L1 TGM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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