EPHA5-RUFY3 Fusion FISH Probe
The EPHA5-RUFY3 Fusion FISH Probe is used to confirm a fusion of the EPHA5 and RUFY3 genes. The fusion of the EPHA5 and RUFY3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHA5-RUFY3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-RERE | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-REOR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-REGO | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-REGR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-OROR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GORE | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GROR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHA5-RUFY3-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHA5 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Gene Name: EPH Receptor A5
Chromosome: CHR4: 66185280 -66535653
Locus: 4q13.1-q13.2
RUFY3 Gene Summary
This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: RUN And FYVE Domain Containing 3
Chromosome: CHR4: 71587695 -71674336
Locus: 4q13.3
Gene Diseases
The EPHA5 RUFY3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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