EPHB1-BFSP2 Fusion FISH Probe
The EPHB1-BFSP2 Fusion FISH Probe is used to confirm a fusion of the EPHB1 and BFSP2 genes. The fusion of the EPHB1 and BFSP2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHB1-BFSP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-RERE | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-REOR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-REGO | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-REGR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-OROR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GORE | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GROR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHB1-BFSP2-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB1 Gene Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
Gene Name: EPH Receptor B1
Chromosome: CHR3: 134514098 -134979307
Locus: 3q22.2
BFSP2 Gene Summary
More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. [provided by RefSeq, Jun 2009]
Gene Name: Beaded Filament Structural Protein 2
Chromosome: CHR3: 133118789 -133194056
Locus: 3q22.1
Gene Diseases
The EPHB1 BFSP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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