EPHB2-NTRK1 Fusion FISH Probe
The EPHB2-NTRK1 Fusion FISH Probe is used to confirm a fusion of the EPHB2 and NTRK1 genes. The fusion of the EPHB2 and NTRK1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHB2-NTRK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-RERE | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-REOR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-REGO | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-REGR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-OROR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GORE | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GROR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHB2-NTRK1-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB2 Gene Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Gene Name: EPH Receptor B2
Chromosome: CHR1: 23037330 -23241823
Locus: 1p36.12
NTRK1 Gene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 1
Chromosome: CHR1: 156785541 -156851642
Locus: 1q23.1
Gene Diseases
The EPHB2 NTRK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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