EPHB3-P2RY12 Fusion FISH Probe
The EPHB3-P2RY12 Fusion FISH Probe is used to confirm a fusion of the EPHB3 and P2RY12 genes. The fusion of the EPHB3 and P2RY12 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHB3-P2RY12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-RERE | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-REOR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-REGO | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-REGR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-OROR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GORE | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GROR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHB3-P2RY12-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB3 Gene Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
Gene Name: EPH Receptor B3
Chromosome: CHR3: 184279586 -184300196
Locus: 3q27.1
P2RY12 Gene Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Name: Purinergic Receptor P2Y12
Chromosome: CHR3: 151055375 -151102544
Locus: 3q25.1
Gene Diseases
The EPHB3 P2RY12 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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