EPHB3-PAX2 Fusion FISH Probe
The EPHB3-PAX2 Fusion FISH Probe is used to confirm a fusion of the EPHB3 and PAX2 genes. The fusion of the EPHB3 and PAX2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHB3-PAX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-RERE | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-REOR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-REGO | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-REGR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-OROR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GORE | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GROR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHB3-PAX2-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB3 Gene Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
Gene Name: EPH Receptor B3
Chromosome: CHR3: 184279586 -184300196
Locus: 3q27.1
PAX2 Gene Summary
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Paired Box 2
Chromosome: CHR10: 102505467 -102589698
Locus: 10q24.31
Gene Diseases
The EPHB3 PAX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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