EPHX2-PTK2B Fusion FISH Probe
The EPHX2-PTK2B Fusion FISH Probe is used to confirm a fusion of the EPHX2 and PTK2B genes. The fusion of the EPHX2 and PTK2B genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPHX2-PTK2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-RERE | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-REOR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-REGO | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-REGR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-REAQ | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-ORRE | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-OROR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-ORGO | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GORE | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GOOR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GOGO | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GOGR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GRRE | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GROR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GRGO | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GRGR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-AQRE | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-AQOR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-AQGO | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-AQGR | 20 (40 μL) | 200 μL |
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| EPHX2-PTK2B-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHX2 Gene Summary
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Name: Epoxide Hydrolase 2
Chromosome: CHR8: 27348644 -27402486
Locus: 8p21.2-p21.1
PTK2B Gene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Kinase 2 Beta
Chromosome: CHR8: 27168998 -27316908
Locus: 8p21.2
Gene Diseases
The EPHX2 PTK2B Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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