EPN2-MAP2K3 Fusion FISH Probe
The EPN2-MAP2K3 Fusion FISH Probe is used to confirm a fusion of the EPN2 and MAP2K3 genes. The fusion of the EPN2 and MAP2K3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EPN2-MAP2K3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| EPN2-MAP2K3-20-AQAQ | 20 (40 μL) | 200 μL |
|
MAP2K3 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 3
Chromosome: CHR17: 21187967 -21218551
Locus: 17p11.2
EPN2 Gene Summary
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Epsin 2
Chromosome: CHR17: 19140689 -19240028
Locus: 17p11.2
Gene Diseases
The EPN2 MAP2K3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|