EPS8-PRH2 Fusion FISH Probe
The EPS8-PRH2 Fusion FISH Probe is used to confirm a fusion of the EPS8 and PRH2 genes. The fusion of the EPS8 and PRH2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPS8-PRH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-RERE | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-REOR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-REGO | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-REGR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-REAQ | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-ORRE | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-OROR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-ORGO | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GORE | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GOOR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GOGO | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GOGR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GRRE | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GROR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GRGO | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GRGR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-AQRE | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-AQOR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-AQGO | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-AQGR | 20 (40 μL) | 200 μL |
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| EPS8-PRH2-20-AQAQ | 20 (40 μL) | 200 μL |
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EPS8 Gene Summary
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Epidermal Growth Factor Receptor Pathway Substrate 8
Chromosome: CHR12: 15773074 -15942510
Locus: 12p12.3
PRH2 Gene Summary
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
Gene Name: Proline Rich Protein HaeIII Subfamily 2
Chromosome: CHR12: 11081833 -11087444
Locus: 12p13.2
Gene Diseases
The EPS8 PRH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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