ERBB2-PSMB3 Fusion FISH Probe
The ERBB2-PSMB3 Fusion FISH Probe is used to confirm a fusion of the ERBB2 and PSMB3 genes. The fusion of the ERBB2 and PSMB3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB2-PSMB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-RERE | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-REOR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-REGO | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-REGR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-REAQ | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-ORRE | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-OROR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-ORGO | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GORE | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GOOR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GOGO | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GOGR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GRRE | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GROR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GRGO | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GRGR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-AQRE | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-AQOR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-AQGO | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-AQGR | 20 (40 μL) | 200 μL |
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| ERBB2-PSMB3-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB2 Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392 -37884915
Locus: 17q12
PSMB3 Gene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]
Gene Name: Proteasome Subunit Beta 3
Chromosome: CHR17: 36909001 -36920478
Locus: 17q12
Gene Diseases
The ERBB2 PSMB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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