ERBB2-SUPT16H Fusion FISH Probe
The ERBB2-SUPT16H Fusion FISH Probe is used to confirm a fusion of the ERBB2 and SUPT16H genes. The fusion of the ERBB2 and SUPT16H genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB2-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| ERBB2-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB2 Gene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 2
Chromosome: CHR17: 37844392 -37884915
Locus: 17q12
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The ERBB2 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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