ERBB3-COX4I2 Fusion FISH Probe
The ERBB3-COX4I2 Fusion FISH Probe is used to confirm a fusion of the ERBB3 and COX4I2 genes. The fusion of the ERBB3 and COX4I2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB3-COX4I2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-RERE | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-REOR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-REGO | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-REGR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-REAQ | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-ORRE | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-OROR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-ORGO | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GORE | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GOOR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GOGO | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GOGR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GRRE | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GROR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GRGO | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GRGR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-AQRE | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-AQOR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-AQGO | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-AQGR | 20 (40 μL) | 200 μL |
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| ERBB3-COX4I2-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
COX4I2 Gene Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome C Oxidase Subunit 4I2
Chromosome: CHR20: 30225690 -30232800
Locus: 20q11.21
Gene Diseases
The ERBB3 COX4I2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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