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ERBB3-FOXA1 Fusion FISH Probe

The ERBB3-FOXA1 Fusion FISH Probe is used to confirm a fusion of the ERBB3 and FOXA1 genes. The fusion of the ERBB3 and FOXA1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ERBB3-FOXA1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ERBB3-FOXA1-20-RERE 20 (40 μL) 200 μL
ERBB3-FOXA1-20-REOR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-REGO 20 (40 μL) 200 μL
ERBB3-FOXA1-20-REGR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-REAQ 20 (40 μL) 200 μL
ERBB3-FOXA1-20-ORRE 20 (40 μL) 200 μL
ERBB3-FOXA1-20-OROR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-ORGO 20 (40 μL) 200 μL
ERBB3-FOXA1-20-ORAQ 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GORE 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GOOR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GOGO 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GOGR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GOAQ 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GRRE 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GROR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GRGO 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GRGR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-GRAQ 20 (40 μL) 200 μL
ERBB3-FOXA1-20-AQRE 20 (40 μL) 200 μL
ERBB3-FOXA1-20-AQOR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-AQGO 20 (40 μL) 200 μL
ERBB3-FOXA1-20-AQGR 20 (40 μL) 200 μL
ERBB3-FOXA1-20-AQAQ 20 (40 μL) 200 μL

ERBB3 Gene Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Name: Erb-b2 Receptor Tyrosine Kinase 3

Chromosome: CHR12: 56473808 -56497291

Locus: 12q13.2

FOXA1 Gene Summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

Gene Name: Forkhead Box A1

Chromosome: CHR14: 38059190 -38064489

Locus: 14q21.1

Gene Diseases

The ERBB3 FOXA1 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.