ERBB3-RPL30 Fusion FISH Probe
The ERBB3-RPL30 Fusion FISH Probe is used to confirm a fusion of the ERBB3 and RPL30 genes. The fusion of the ERBB3 and RPL30 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB3-RPL30-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-RERE | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-REOR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-REGO | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-REGR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-REAQ | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-ORRE | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-OROR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-ORGO | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GORE | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GOOR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GOGO | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GOGR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GRRE | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GROR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GRGO | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GRGR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-AQRE | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-AQOR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-AQGO | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-AQGR | 20 (40 μL) | 200 μL |
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| ERBB3-RPL30-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
RPL30 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L30
Chromosome: CHR8: 99053937 -99057818
Locus: 8q22.2
Gene Diseases
The ERBB3 RPL30 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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