ERBB3-SUOX Fusion FISH Probe
The ERBB3-SUOX Fusion FISH Probe is used to confirm a fusion of the ERBB3 and SUOX genes. The fusion of the ERBB3 and SUOX genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERBB3-SUOX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-RERE | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-REOR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-REGO | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-REGR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-REAQ | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-ORRE | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-OROR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-ORGO | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GORE | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GOOR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GOGO | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GOGR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GRRE | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GROR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GRGO | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GRGR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-AQRE | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-AQOR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-AQGO | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-AQGR | 20 (40 μL) | 200 μL |
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| ERBB3-SUOX-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
SUOX Gene Summary
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Gene Name: Sulfite Oxidase
Chromosome: CHR12: 56391042 -56399309
Locus: 12q13.2
Gene Diseases
The ERBB3 SUOX Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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