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ERC1-MRPL51 Fusion FISH Probe

The ERC1-MRPL51 Fusion FISH Probe is used to confirm a fusion of the ERC1 and MRPL51 genes. The fusion of the ERC1 and MRPL51 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ERC1-MRPL51-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ERC1-MRPL51-20-RERE 20 (40 μL) 200 μL
ERC1-MRPL51-20-REOR 20 (40 μL) 200 μL
ERC1-MRPL51-20-REGO 20 (40 μL) 200 μL
ERC1-MRPL51-20-REGR 20 (40 μL) 200 μL
ERC1-MRPL51-20-REAQ 20 (40 μL) 200 μL
ERC1-MRPL51-20-ORRE 20 (40 μL) 200 μL
ERC1-MRPL51-20-OROR 20 (40 μL) 200 μL
ERC1-MRPL51-20-ORGO 20 (40 μL) 200 μL
ERC1-MRPL51-20-ORAQ 20 (40 μL) 200 μL
ERC1-MRPL51-20-GORE 20 (40 μL) 200 μL
ERC1-MRPL51-20-GOOR 20 (40 μL) 200 μL
ERC1-MRPL51-20-GOGO 20 (40 μL) 200 μL
ERC1-MRPL51-20-GOGR 20 (40 μL) 200 μL
ERC1-MRPL51-20-GOAQ 20 (40 μL) 200 μL
ERC1-MRPL51-20-GRRE 20 (40 μL) 200 μL
ERC1-MRPL51-20-GROR 20 (40 μL) 200 μL
ERC1-MRPL51-20-GRGO 20 (40 μL) 200 μL
ERC1-MRPL51-20-GRGR 20 (40 μL) 200 μL
ERC1-MRPL51-20-GRAQ 20 (40 μL) 200 μL
ERC1-MRPL51-20-AQRE 20 (40 μL) 200 μL
ERC1-MRPL51-20-AQOR 20 (40 μL) 200 μL
ERC1-MRPL51-20-AQGO 20 (40 μL) 200 μL
ERC1-MRPL51-20-AQGR 20 (40 μL) 200 μL
ERC1-MRPL51-20-AQAQ 20 (40 μL) 200 μL

ERC1 Gene Summary

The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Name: ELKS/RAB6-interacting/CAST Family Member 1

Chromosome: CHR12: 1100403 -1605099

Locus: 12p13.33

MRPL51 Gene Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]

Gene Name: Mitochondrial Ribosomal Protein L51

Chromosome: CHR12: 6601315 -6602471

Locus: 12p13.31

Gene Diseases

The ERC1 MRPL51 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.