ERC1-RET Fusion FISH Probe
The ERC1-RET Fusion FISH Probe is used to confirm a fusion of the ERC1 and RET genes. The fusion of the ERC1 and RET genes has been associated with Breast Invasive Carcinoma, Thyroid Carcinoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERC1-RET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-RERE | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-REOR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-REGO | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-REGR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-REAQ | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-ORRE | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-OROR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-ORGO | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GORE | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GOOR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GOGO | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GOGR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GRRE | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GROR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GRGO | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GRGR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-AQRE | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-AQOR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-AQGO | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-AQGR | 20 (40 μL) | 200 μL |
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| ERC1-RET-20-AQAQ | 20 (40 μL) | 200 μL |
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RET Gene Summary
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Gene Name: Ret Proto-oncogene
Chromosome: CHR10: 43572516 -43625797
Locus: 10q11.21
ERC1 Gene Summary
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: ELKS/RAB6-interacting/CAST Family Member 1
Chromosome: CHR12: 1100403 -1605099
Locus: 12p13.33
Gene Diseases
The ERC1 RET Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Thyroid Carcinoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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