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ERG-ZNRF3 Fusion FISH Probe

The ERG-ZNRF3 Fusion FISH Probe is used to confirm a fusion of the ERG and ZNRF3 genes. The fusion of the ERG and ZNRF3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ERG-ZNRF3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ERG-ZNRF3-20-RERE 20 (40 μL) 200 μL
ERG-ZNRF3-20-REOR 20 (40 μL) 200 μL
ERG-ZNRF3-20-REGO 20 (40 μL) 200 μL
ERG-ZNRF3-20-REGR 20 (40 μL) 200 μL
ERG-ZNRF3-20-REAQ 20 (40 μL) 200 μL
ERG-ZNRF3-20-ORRE 20 (40 μL) 200 μL
ERG-ZNRF3-20-OROR 20 (40 μL) 200 μL
ERG-ZNRF3-20-ORGO 20 (40 μL) 200 μL
ERG-ZNRF3-20-ORAQ 20 (40 μL) 200 μL
ERG-ZNRF3-20-GORE 20 (40 μL) 200 μL
ERG-ZNRF3-20-GOOR 20 (40 μL) 200 μL
ERG-ZNRF3-20-GOGO 20 (40 μL) 200 μL
ERG-ZNRF3-20-GOGR 20 (40 μL) 200 μL
ERG-ZNRF3-20-GOAQ 20 (40 μL) 200 μL
ERG-ZNRF3-20-GRRE 20 (40 μL) 200 μL
ERG-ZNRF3-20-GROR 20 (40 μL) 200 μL
ERG-ZNRF3-20-GRGO 20 (40 μL) 200 μL
ERG-ZNRF3-20-GRGR 20 (40 μL) 200 μL
ERG-ZNRF3-20-GRAQ 20 (40 μL) 200 μL
ERG-ZNRF3-20-AQRE 20 (40 μL) 200 μL
ERG-ZNRF3-20-AQOR 20 (40 μL) 200 μL
ERG-ZNRF3-20-AQGO 20 (40 μL) 200 μL
ERG-ZNRF3-20-AQGR 20 (40 μL) 200 μL
ERG-ZNRF3-20-AQAQ 20 (40 μL) 200 μL

ERG Gene Summary

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Gene Name: ERG, ETS Transcription Factor

Chromosome: CHR21: 39739182 -40033618

Locus: 21q22.2

ZNRF3 Gene Summary

The Zinc And Ring Finger 3 (ZNRF3) gene is located on chr22 :29279754-29453476 at 22q12.1.

Gene Name: Zinc And Ring Finger 3

Chromosome: CHR22: 29279754 -29453476

Locus: 22q12.1

Gene Diseases

The ERG ZNRF3 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.