ERN1-TEX2 Fusion FISH Probe
The ERN1-TEX2 Fusion FISH Probe is used to confirm a fusion of the ERN1 and TEX2 genes. The fusion of the ERN1 and TEX2 genes has been associated with Liver Hepatocellular Carcinoma, Liver Hepatocellular Carcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERN1-TEX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-RERE | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-REOR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-REGO | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-REGR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-REAQ | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-ORRE | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-OROR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-ORGO | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GORE | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GOOR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GOGO | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GOGR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GRRE | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GROR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GRGO | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GRGR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-AQRE | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-AQOR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-AQGO | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-AQGR | 20 (40 μL) | 200 μL |
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| ERN1-TEX2-20-AQAQ | 20 (40 μL) | 200 μL |
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ERN1 Gene Summary
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Gene Name: Endoplasmic Reticulum To Nucleus Signaling 1
Chromosome: CHR17: 62120389 -62207502
Locus: 17q23.3
TEX2 Gene Summary
The Testis Expressed 2 (TEX2) gene is located on chr17 :62224794-62340653 at 17q23.3.
Gene Name: Testis Expressed 2
Chromosome: CHR17: 62224794 -62340653
Locus: 17q23.3
Gene Diseases
The ERN1 TEX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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