ESR1-ASPH Fusion FISH Probe
The ESR1-ASPH Fusion FISH Probe is used to confirm a fusion of the ESR1 and ASPH genes. The fusion of the ESR1 and ASPH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ESR1-ASPH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-RERE | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-REOR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-REGO | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-REGR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-REAQ | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-ORRE | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-OROR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-ORGO | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-ORAQ | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GORE | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GOOR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GOGO | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GOGR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GOAQ | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GRRE | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GROR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GRGO | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GRGR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-GRAQ | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-AQRE | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-AQOR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-AQGO | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-AQGR | 20 (40 μL) | 200 μL |
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| ESR1-ASPH-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
ESR1 Gene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Gene Name: Estrogen Receptor 1
Chromosome: CHR6: 152011630 -152424408
Locus: 6q25.1-q25.2
Gene Diseases
The ESR1 ASPH Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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