ETV6-NTRK3 Fusion FISH Probe
The ETV6-NTRK3 Fusion FISH Probe is used to confirm a fusion of the ETV6 and NTRK3 genes. The fusion of the ETV6 and NTRK3 genes has been associated with Breast Invasive Carcinoma, Thyroid Carcinoma, Colon Adenocarcinoma, Colon Adenocarcinoma, Thyroid Carcinoma, Thyroid Carcinoma, Thyroid Carcinoma, Skin Cutaneous Melanoma, Thyroid Carcinoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ETV6-NTRK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ETV6-NTRK3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ETV6 Gene Summary
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Gene Name: ETS Variant 6
Chromosome: CHR12: 11802787 -12048325
Locus: 12p13.2
NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 3
Chromosome: CHR15: 88419987 -88799962
Locus: 15q25.3
Gene Diseases
The ETV6 NTRK3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
| Thyroid Carcinoma |
| Colon Adenocarcinoma |
| Colon Adenocarcinoma |
| Thyroid Carcinoma |
| Thyroid Carcinoma |
| Thyroid Carcinoma |
| Skin Cutaneous Melanoma |
| Thyroid Carcinoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|