EVPL-MAP2K6 Fusion FISH Probe
The EVPL-MAP2K6 Fusion FISH Probe is used to confirm a fusion of the EVPL and MAP2K6 genes. The fusion of the EVPL and MAP2K6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EVPL-MAP2K6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-RERE | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-REOR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-REGO | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-REGR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-REAQ | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-ORRE | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-OROR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-ORGO | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-ORAQ | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GORE | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GOOR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GOGO | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GOGR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GOAQ | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GRRE | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GROR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GRGO | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GRGR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-GRAQ | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-AQRE | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-AQOR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-AQGO | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-AQGR | 20 (40 μL) | 200 μL |
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| EVPL-MAP2K6-20-AQAQ | 20 (40 μL) | 200 μL |
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EVPL Gene Summary
This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
Gene Name: Envoplakin
Chromosome: CHR17: 74002926 -74023507
Locus: 17q25.1
MAP2K6 Gene Summary
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 6
Chromosome: CHR17: 67410837 -67538470
Locus: 17q24.3
Gene Diseases
The EVPL MAP2K6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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