FANCI-HADHB Fusion FISH Probe
The FANCI-HADHB Fusion FISH Probe is used to confirm a fusion of the FANCI and HADHB genes. The fusion of the FANCI and HADHB genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FANCI-HADHB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-RERE | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-REOR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-REGO | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-REGR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-REAQ | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-ORRE | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-OROR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-ORGO | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-ORAQ | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GORE | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GOOR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GOGO | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GOGR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GOAQ | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GRRE | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GROR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GRGO | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GRGR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-GRAQ | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-AQRE | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-AQOR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-AQGO | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-AQGR | 20 (40 μL) | 200 μL |
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| FANCI-HADHB-20-AQAQ | 20 (40 μL) | 200 μL |
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HADHB Gene Summary
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Gene Name: Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta
Chromosome: CHR2: 26467615 -26513333
Locus: 2p23.3
FANCI Gene Summary
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Fanconi Anemia Complementation Group I
Chromosome: CHR15: 89787193 -89860362
Locus: 15q26.1
Gene Diseases
The FANCI HADHB Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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