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FAT1-IRF2 Fusion FISH Probe

The FAT1-IRF2 Fusion FISH Probe is used to confirm a fusion of the FAT1 and IRF2 genes. The fusion of the FAT1 and IRF2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FAT1-IRF2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FAT1-IRF2-20-RERE 20 (40 μL) 200 μL
FAT1-IRF2-20-REOR 20 (40 μL) 200 μL
FAT1-IRF2-20-REGO 20 (40 μL) 200 μL
FAT1-IRF2-20-REGR 20 (40 μL) 200 μL
FAT1-IRF2-20-REAQ 20 (40 μL) 200 μL
FAT1-IRF2-20-ORRE 20 (40 μL) 200 μL
FAT1-IRF2-20-OROR 20 (40 μL) 200 μL
FAT1-IRF2-20-ORGO 20 (40 μL) 200 μL
FAT1-IRF2-20-ORAQ 20 (40 μL) 200 μL
FAT1-IRF2-20-GORE 20 (40 μL) 200 μL
FAT1-IRF2-20-GOOR 20 (40 μL) 200 μL
FAT1-IRF2-20-GOGO 20 (40 μL) 200 μL
FAT1-IRF2-20-GOGR 20 (40 μL) 200 μL
FAT1-IRF2-20-GOAQ 20 (40 μL) 200 μL
FAT1-IRF2-20-GRRE 20 (40 μL) 200 μL
FAT1-IRF2-20-GROR 20 (40 μL) 200 μL
FAT1-IRF2-20-GRGO 20 (40 μL) 200 μL
FAT1-IRF2-20-GRGR 20 (40 μL) 200 μL
FAT1-IRF2-20-GRAQ 20 (40 μL) 200 μL
FAT1-IRF2-20-AQRE 20 (40 μL) 200 μL
FAT1-IRF2-20-AQOR 20 (40 μL) 200 μL
FAT1-IRF2-20-AQGO 20 (40 μL) 200 μL
FAT1-IRF2-20-AQGR 20 (40 μL) 200 μL
FAT1-IRF2-20-AQAQ 20 (40 μL) 200 μL

FAT1 Gene Summary

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Gene Name: FAT Atypical Cadherin 1

Chromosome: CHR4: 187508936 -187644987

Locus: 4q35.2

IRF2 Gene Summary

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

Gene Name: Interferon Regulatory Factor 2

Chromosome: CHR4: 185308875 -185395726

Locus: 4q35.1

Gene Diseases

The FAT1 IRF2 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.