FBL-SEC63 Fusion FISH Probe
The FBL-SEC63 Fusion FISH Probe is used to confirm a fusion of the FBL and SEC63 genes. The fusion of the FBL and SEC63 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBL-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| FBL-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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FBL Gene Summary
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Gene Name: Fibrillarin
Chromosome: CHR19: 40325092 -40337054
Locus: 19q13.2
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The FBL SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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