FBLIM1-DNAH14 Fusion FISH Probe
The FBLIM1-DNAH14 Fusion FISH Probe is used to confirm a fusion of the FBLIM1 and DNAH14 genes. The fusion of the FBLIM1 and DNAH14 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBLIM1-DNAH14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-RERE | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-REOR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-REGO | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-REGR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-REAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-ORRE | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-OROR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-ORGO | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GORE | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GOOR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GOGO | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GOGR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GRRE | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GROR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GRGO | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GRGR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-AQRE | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-AQOR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-AQGO | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-AQGR | 20 (40 μL) | 200 μL |
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| FBLIM1-DNAH14-20-AQAQ | 20 (40 μL) | 200 μL |
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FBLIM1 Gene Summary
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Filamin Binding LIM Protein 1
Chromosome: CHR1: 16085254 -16113084
Locus: 1p36.21
DNAH14 Gene Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Gene Name: Dynein Axonemal Heavy Chain 14
Chromosome: CHR1: 225117355 -225586996
Locus: 1q42.12
Gene Diseases
The FBLIM1 DNAH14 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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