FBXL7-FOSL2 Fusion FISH Probe
The FBXL7-FOSL2 Fusion FISH Probe is used to confirm a fusion of the FBXL7 and FOSL2 genes. The fusion of the FBXL7 and FOSL2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXL7-FOSL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FBXL7-FOSL2-20-AQAQ | 20 (40 μL) | 200 μL |
|
FOSL2 Gene Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Gene Name: FOS Like 2, AP-1 Transcription Factor Subunit
Chromosome: CHR2: 28615778 -28637516
Locus: 2p23.2
FBXL7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: F-box And Leucine Rich Repeat Protein 7
Chromosome: CHR5: 15500304 -15939900
Locus: 5p15.1
Gene Diseases
The FBXL7 FOSL2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|