FBXL7-PTPN3 Fusion FISH Probe
The FBXL7-PTPN3 Fusion FISH Probe is used to confirm a fusion of the FBXL7 and PTPN3 genes. The fusion of the FBXL7 and PTPN3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL7-PTPN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL7-PTPN3-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN3 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 3
Chromosome: CHR9: 112137973 -112260593
Locus: 9q31.3
FBXL7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: F-box And Leucine Rich Repeat Protein 7
Chromosome: CHR5: 15500304 -15939900
Locus: 5p15.1
Gene Diseases
The FBXL7 PTPN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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