FBXO31-ZNRF1 Fusion FISH Probe
The FBXO31-ZNRF1 Fusion FISH Probe is used to confirm a fusion of the FBXO31 and ZNRF1 genes. The fusion of the FBXO31 and ZNRF1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO31-ZNRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO31-ZNRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXO31 Gene Summary
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: F-box Protein 31
Chromosome: CHR16: 87362941 -87425708
Locus: 16q24.2
ZNRF1 Gene Summary
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Gene Name: Zinc And Ring Finger 1
Chromosome: CHR16: 75032914 -75144892
Locus: 16q23.1
Gene Diseases
The FBXO31 ZNRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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