FBXW2-LTBP2 Fusion FISH Probe
The FBXW2-LTBP2 Fusion FISH Probe is used to confirm a fusion of the FBXW2 and LTBP2 genes. The fusion of the FBXW2 and LTBP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW2-LTBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW2-LTBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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LTBP2 Gene Summary
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
Gene Name: Latent Transforming Growth Factor Beta Binding Protein 2
Chromosome: CHR14: 74964885 -75079034
Locus: 14q24.3
FBXW2 Gene Summary
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 2
Chromosome: CHR9: 123519253 -123555740
Locus: 9q33.2
Gene Diseases
The FBXW2 LTBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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