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FBXW2-NXNL2 Fusion FISH Probe

The FBXW2-NXNL2 Fusion FISH Probe is used to confirm a fusion of the FBXW2 and NXNL2 genes. The fusion of the FBXW2 and NXNL2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FBXW2-NXNL2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FBXW2-NXNL2-20-RERE 20 (40 μL) 200 μL
FBXW2-NXNL2-20-REOR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-REGO 20 (40 μL) 200 μL
FBXW2-NXNL2-20-REGR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-REAQ 20 (40 μL) 200 μL
FBXW2-NXNL2-20-ORRE 20 (40 μL) 200 μL
FBXW2-NXNL2-20-OROR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-ORGO 20 (40 μL) 200 μL
FBXW2-NXNL2-20-ORAQ 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GORE 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GOOR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GOGO 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GOGR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GOAQ 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GRRE 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GROR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GRGO 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GRGR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-GRAQ 20 (40 μL) 200 μL
FBXW2-NXNL2-20-AQRE 20 (40 μL) 200 μL
FBXW2-NXNL2-20-AQOR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-AQGO 20 (40 μL) 200 μL
FBXW2-NXNL2-20-AQGR 20 (40 μL) 200 μL
FBXW2-NXNL2-20-AQAQ 20 (40 μL) 200 μL

FBXW2 Gene Summary

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

Gene Name: F-box And WD Repeat Domain Containing 2

Chromosome: CHR9: 123519253 -123555740

Locus: 9q33.2

NXNL2 Gene Summary

The Nucleoredoxin Like 2 (NXNL2) gene is located on chr9 :91150015-91190704 at 9q22.1.

Gene Name: Nucleoredoxin Like 2

Chromosome: CHR9: 91150015 -91190704

Locus: 9q22.1

Gene Diseases

The FBXW2 NXNL2 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.