GAPDH-HSPB1 Fusion FISH Probe
The GAPDH-HSPB1 Fusion FISH Probe is used to confirm a fusion of the GAPDH and HSPB1 genes. The fusion of the GAPDH and HSPB1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GAPDH-HSPB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-RERE | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-REOR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-REGO | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-REGR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-REAQ | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-ORRE | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-OROR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-ORGO | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GORE | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GOOR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GOGO | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GOGR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GRRE | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GROR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GRGO | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GRGR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-AQRE | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-AQOR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-AQGO | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-AQGR | 20 (40 μL) | 200 μL |
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| GAPDH-HSPB1-20-AQAQ | 20 (40 μL) | 200 μL |
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GAPDH Gene Summary
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Gene Name: Glyceraldehyde-3-phosphate Dehydrogenase
Chromosome: CHR12: 6643656 -6647536
Locus: 12p13.31
HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
Gene Diseases
The GAPDH HSPB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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