GBF1-TRPC6 Fusion FISH Probe
The GBF1-TRPC6 Fusion FISH Probe is used to confirm a fusion of the GBF1 and TRPC6 genes. The fusion of the GBF1 and TRPC6 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GBF1-TRPC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-RERE | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-REOR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-REGO | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-REGR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-REAQ | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-ORRE | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-OROR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-ORGO | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GORE | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GOOR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GOGO | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GOGR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GRRE | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GROR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GRGO | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GRGR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-AQRE | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-AQOR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-AQGO | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-AQGR | 20 (40 μL) | 200 μL |
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| GBF1-TRPC6-20-AQAQ | 20 (40 μL) | 200 μL |
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TRPC6 Gene Summary
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Gene Name: Transient Receptor Potential Cation Channel Subfamily C Member 6
Chromosome: CHR11: 101322294 -101454659
Locus: 11q22.1
GBF1 Gene Summary
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1
Chromosome: CHR10: 104005254 -104142656
Locus: 10q24.32
Gene Diseases
The GBF1 TRPC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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