GPC4-GPC3 Fusion FISH Probe
The GPC4-GPC3 Fusion FISH Probe is used to confirm a fusion of the GPC4 and GPC3 genes. The fusion of the GPC4 and GPC3 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPC4-GPC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-RERE | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-REOR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-REGO | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-REGR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-REAQ | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-ORRE | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-OROR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-ORGO | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GORE | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GOOR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GOGO | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GOGR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GRRE | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GROR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GRGO | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GRGR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-AQRE | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-AQOR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-AQGO | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-AQGR | 20 (40 μL) | 200 μL |
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| GPC4-GPC3-20-AQAQ | 20 (40 μL) | 200 μL |
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GPC4 Gene Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Glypican 4
Chromosome: CHRX: 132435063 -132549205
Locus: Xq26.2
GPC3 Gene Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Glypican 3
Chromosome: CHRX: 132669775 -133119673
Locus: Xq26.2
Gene Diseases
The GPC4 GPC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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