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GPHN-PRKCH Fusion FISH Probe

The GPHN-PRKCH Fusion FISH Probe is used to confirm a fusion of the GPHN and PRKCH genes. The fusion of the GPHN and PRKCH genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
GPHN-PRKCH-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
GPHN-PRKCH-20-RERE 20 (40 μL) 200 μL
GPHN-PRKCH-20-REOR 20 (40 μL) 200 μL
GPHN-PRKCH-20-REGO 20 (40 μL) 200 μL
GPHN-PRKCH-20-REGR 20 (40 μL) 200 μL
GPHN-PRKCH-20-REAQ 20 (40 μL) 200 μL
GPHN-PRKCH-20-ORRE 20 (40 μL) 200 μL
GPHN-PRKCH-20-OROR 20 (40 μL) 200 μL
GPHN-PRKCH-20-ORGO 20 (40 μL) 200 μL
GPHN-PRKCH-20-ORAQ 20 (40 μL) 200 μL
GPHN-PRKCH-20-GORE 20 (40 μL) 200 μL
GPHN-PRKCH-20-GOOR 20 (40 μL) 200 μL
GPHN-PRKCH-20-GOGO 20 (40 μL) 200 μL
GPHN-PRKCH-20-GOGR 20 (40 μL) 200 μL
GPHN-PRKCH-20-GOAQ 20 (40 μL) 200 μL
GPHN-PRKCH-20-GRRE 20 (40 μL) 200 μL
GPHN-PRKCH-20-GROR 20 (40 μL) 200 μL
GPHN-PRKCH-20-GRGO 20 (40 μL) 200 μL
GPHN-PRKCH-20-GRGR 20 (40 μL) 200 μL
GPHN-PRKCH-20-GRAQ 20 (40 μL) 200 μL
GPHN-PRKCH-20-AQRE 20 (40 μL) 200 μL
GPHN-PRKCH-20-AQOR 20 (40 μL) 200 μL
GPHN-PRKCH-20-AQGO 20 (40 μL) 200 μL
GPHN-PRKCH-20-AQGR 20 (40 μL) 200 μL
GPHN-PRKCH-20-AQAQ 20 (40 μL) 200 μL

PRKCH Gene Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

Gene Name: Protein Kinase C Eta

Chromosome: CHR14: 61788514 -62017698

Locus: 14q23.1

GPHN Gene Summary

This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]

Gene Name: Gephyrin

Chromosome: CHR14: 66974124 -67648525

Locus: 14q23.3-q24.1

Gene Diseases

The GPHN PRKCH Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.