GPNMB-KLHL7 Fusion FISH Probe
The GPNMB-KLHL7 Fusion FISH Probe is used to confirm a fusion of the GPNMB and KLHL7 genes. The fusion of the GPNMB and KLHL7 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPNMB-KLHL7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-RERE | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-REOR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-REGO | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-REGR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-REAQ | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-ORRE | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-OROR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-ORGO | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GORE | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GOOR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GOGO | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GOGR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GRRE | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GROR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GRGO | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GRGR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-AQRE | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-AQOR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-AQGO | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-AQGR | 20 (40 μL) | 200 μL |
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| GPNMB-KLHL7-20-AQAQ | 20 (40 μL) | 200 μL |
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GPNMB Gene Summary
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glycoprotein Nmb
Chromosome: CHR7: 23286315 -23314729
Locus: 7p15.3
KLHL7 Gene Summary
This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]
Gene Name: Kelch Like Family Member 7
Chromosome: CHR7: 23145352 -23215038
Locus: 7p15.3
Gene Diseases
The GPNMB KLHL7 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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