GPX3-CHD4 Fusion FISH Probe
The GPX3-CHD4 Fusion FISH Probe is used to confirm a fusion of the GPX3 and CHD4 genes. The fusion of the GPX3 and CHD4 genes has been associated with Thyroid Carcinoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPX3-CHD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-RERE | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-REOR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-REGO | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-REGR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-REAQ | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-ORRE | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-OROR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-ORGO | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GORE | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GOOR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GOGO | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GOGR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GRRE | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GROR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GRGO | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GRGR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-AQRE | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-AQOR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-AQGO | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-AQGR | 20 (40 μL) | 200 μL |
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| GPX3-CHD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHD4 Gene Summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Chromodomain Helicase DNA Binding Protein 4
Chromosome: CHR12: 6679247 -6716551
Locus: 12p13.31
GPX3 Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Name: Glutathione Peroxidase 3
Chromosome: CHR5: 150399998 -150408554
Locus: 5q33.1
Gene Diseases
The GPX3 CHD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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