GPX3-CLCN3 Fusion FISH Probe
The GPX3-CLCN3 Fusion FISH Probe is used to confirm a fusion of the GPX3 and CLCN3 genes. The fusion of the GPX3 and CLCN3 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPX3-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| GPX3-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
GPX3 Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Name: Glutathione Peroxidase 3
Chromosome: CHR5: 150399998 -150408554
Locus: 5q33.1
Gene Diseases
The GPX3 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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