GPX3-EIF2AK2 Fusion FISH Probe
The GPX3-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the GPX3 and EIF2AK2 genes. The fusion of the GPX3 and EIF2AK2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GPX3-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| GPX3-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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GPX3 Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Name: Glutathione Peroxidase 3
Chromosome: CHR5: 150399998 -150408554
Locus: 5q33.1
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The GPX3 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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