GRAP2-BRD1 Fusion FISH Probe
The GRAP2-BRD1 Fusion FISH Probe is used to confirm a fusion of the GRAP2 and BRD1 genes. The fusion of the GRAP2 and BRD1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRAP2-BRD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-RERE | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-REOR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-REGO | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-REGR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-REAQ | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-ORRE | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-OROR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-ORGO | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GORE | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GOOR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GOGO | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GOGR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GRRE | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GROR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GRGO | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GRGR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-AQRE | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-AQOR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-AQGO | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-AQGR | 20 (40 μL) | 200 μL |
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| GRAP2-BRD1-20-AQAQ | 20 (40 μL) | 200 μL |
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GRAP2 Gene Summary
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Name: GRB2-related Adaptor Protein 2
Chromosome: CHR22: 40297085 -40367384
Locus: 22q13.1
BRD1 Gene Summary
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Gene Name: Bromodomain Containing 1
Chromosome: CHR22: 50166936 -50218452
Locus: 22q13.33
Gene Diseases
The GRAP2 BRD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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